PEGylated Proteins
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… Protein PEGylation is a great tool to improve the delivery of therapeutic proteins, but it adds a level of complexity to the product. As well as the characterisation of individual components (PEG and protein), …
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… Absolute quantification of proteins ( i.e. quantification without the need for a … a very precise and very accurate absolute quantification of proteins. Compared to the reference method (amino acid … developed in our labs for the absolute quantification of proteins by ICP/MS. This method holds the potential to …
Absolute quantification of proteins by ICP/MS
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… other hand, the LC-MS/MS determination of specific tryptic peptides lacks reproducibility due to the variability of the …
Characterisation of proteins by MS
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… range of technologies to fully characterise therapeutic proteins. Whether you are interested in monoclonal … antibodies (mAbs), antibody-drug conjugates (ADCs), fusion proteins, small or large proteins, Quality Assistance has the tools to support you for the characterisation of drug substances and drug products, QC …
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… and subunit analysis. Applications of these methods to mAbs (Humira ® , Erbitux ® ) and highly glycosylated …
Protein aggregation
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… Protein aggregation is a major concern for biotherapeutics … there is still no specific guidance on biopharmaceutical protein aggregates, regulatory agencies have clearly highlighted the need for the in-depth characterisation and monitoring of aggregation. Quality …
Our webinar is online: Mass spectrometry toolkit for the characterisation of protein glycosylation
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… Assistance webinar Mass spectrometry toolkit for the characterisation of protein glycosylation given on July 12th at 16.00 … Due to their mode of production, therapeutic glycoproteins present complex and heterogeneous glycosylations. …
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… approach to be easily applied for different proteins or peptides even in matrices containing low molecular weight …
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… Abstract Almost 60% of commercialized pharmaceutical proteins are glycosylated. Glycosylation is considered a … as it affects the stability, bioactivity and safety of proteins. Hence, the development of analytical methods to characterise the composition and structure of glycoproteins is crucial. Currently, existing methods are …