… Oligonucleotides have been in clinical development for approximately 30 years. Anti-sense oligonucleotides and aptamers were initially developed, … numerous clinical trials were performed and thousands of oligonucleotides underwent studies for a possible market …

… an analytical method for the absolute quantification of oligonucleotides is a prerequisite. In this application … by triple quadrupole ICP-MS for the quantification of oligonucleotides in drug substances and drug products. The … the method was studied in terms of precision and accuracy. Oligonucleotides are a promising class of therapeutics, that …

… digestion of the sample: accurate quantification of oligonucleotides can be performed using the fixed … Sodium may also be determined with the same method. … Oligonucleotides: Absolute quantification and P=O/P=S in a …

… is a critical quality attribute of phosphorothioate oligonucleotides. The determination of this ratio is … samples. The method could be used in routine testing of oligonucleotides in a GxP environment, as an orthogonal … is a critical quality attribute of phosphorothioate oligonucleotides. The determination of this ratio is …

… is a critical quality attribute of phosphorothioate oligonucleotides.  Quality Assistance  developed an  …  by ICP-MS/MS to allow: Accurate quantification of oligonucleotides, without reference substance Easy … determine the P=O/P=S ratio in oligonucleotide samples. … OLIGONUCLEOTIDES: absolute quantification and P=O/P=S …

… is a critical quality attribute of phosphorothioate oligonucleotides. The determination of this ratio is … samples. The method could be used in routine testing of oligonucleotides in a GxP environment, as an orthogonal … be a solution for a fast and accurate generic method for oligonucleotides quantification without the reference oligo …

… The field of therapeutic oligonucleotides has seen remarkable progress over the last years . Oligonucleotides have emerged as promising candidates for … silencing, such as short interfering RNA (siRNA), antisense oligonucleotides (ASOs), microRNA (miRNA) and aptamers. …

… Oligonucleotides have been in clinical development for the … clear clinical benefit in rigorously controlled trials. Oligonucleotides are synthetised by a chemical process. … oligonucleotide of interest of a given length n but also oligonucleotides of unwanted length, such as n-1 …