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Characterisation of the glycosylation of Humira (adalimumab) and Erbitux (Cetuximab) by high resolution mass spectrometry

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… HILIC/MS, after triple enzymatic digestion, yielding short peptides and a complete sequence coverage. This stationary … phase allows a complete resolution of glycosylated peptides vs. aglycosylated peptides, and MSE data provides a confirmation of the …

TIDES Europe

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… the forefront of analytical sciences. We are experts in... OLIGONUCLEOTIDES Due to their relatively large size as … many technical challenges associated with the analysis of oligonucleotides . With a highly experienced staff and … was the chairperson of the Analytical Strategies for Oligonucleotides, Peptides and mRNA Products workshop. …

EuroTIDES 2018

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… the registration process. Peptide expertise Therapeutic peptides are at the crossroads of small molecules and …

TIDES Europe 2019

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… the registration process. Peptide expertise Therapeutic peptides are at the crossroads of small molecules and …

Always at the forefront of analytical sciences

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… amongst which: Molecular weight determination (for mAbs , ADCs , oligonucleotides , peptides and vaccines ) Glycan …

TIDES Europe 2020

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… many technical challenges associated with the analysis of oligonucleotides . With a highly experienced staff and … analytical hurdles and facilitate the registration process. OLIGONUCLEOTIDES: absolute quantification and P=O/P=S … is a critical quality attribute of phosphorothioate oligonucleotides. Quality Assistance developed an ICP-MS/MS …

TIDES Europe 2022

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TIDES US 2018

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… and technical support for the development of your peptides and oligonucleotides. Our added-value brings …

Evaluation of TCR-pMHC affinity and its implications for T cell responsiveness

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… classes of T cells. Cytotoxic CD8+ T lymphocytes recognise peptides presented by MHC class I molecules, while CD4+ T helper lymphocytes recognise peptides presented by MHC class II molecules. MHC class I …

State-of-the-Art MS Methods for Structural Assessment of mAbs and ADCs: From the Research Lab to Routine Characterization

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… MS Methods for Structural Assessment of mAbs and ADCs : From the Research Lab to Routine Characterization By … candidates. This is also true for antibody–drug conjugates (ADCs). These immunoconjugates are based on highly cytotoxic … next-generation empowered biologics for cancer treatment. ADCs are more complex than naked mAbs, because the …