SoloVPE

The SoloVPE (Variable Pathlength Extension) system provides a reliable solution for concentration measurement and extinction coefficient determination across all stages of product development. It enables rapid analysis of samples, including highly concentrated ones, in a fully GxP‑compliant environment.

Advantages of the equipment

• Measures highly concentrated samples without dilution, using volumes from <10 µL to 2.5 mL depending on the vessel and the properties of the sample
• Delivers rapid and easy‑to‑use concentration measurements.
• Ensures linearity verification through multiple absorbance data points and real‑time slope analysis.

Applications / Use cases

The technology is applicable from discovery to quality control, including stability studies and batch‑to‑batch consistency evaluation. It is also used for extinction coefficient determination when sample concentration is known.

Although this system is able to analyse a wide range of samples, the main application at Quality Assistance is the determination of protein concentration in therapeutic protein samples. Especially for high-concentration samples, the Slope Spectroscopy technique will provide high quality results, without the need for baseline correction and manual sample dilution steps that usually impact variability method performance.