Resources
… Due to their mode of production, therapeutic glycoproteins present complex and heterogeneous glycosylations. … as a powerful tool for Etanercept glycosylation characterisation is presented. Using a comprehensive … comprehensive workflow is fully applicable to other glycoproteins, such as mAbs, ADCs, and other proteins produced by …
Resources
… for each level of information you need (from intact protein to peptides/amino acids). Analytical performance of … is a very powerful technique widely used for the characterisation of biopharmaceuticals. Thanks to … antibodies, based on three levels of analysis: Intact protein, mAb substructures (after IdeS / FabRICATOR …
Protein aggregation
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… Protein aggregation is a major concern for biotherapeutics … there is still no specific guidance on biopharmaceutical protein aggregates, regulatory agencies have clearly highlighted the need for the in-depth characterisation and monitoring of aggregation. Quality …
Resources
… of antibodies is a complex and lengthy process. In-process characterisation of the mAb would help in optimising the production steps . Efficiency in mAb characterisation can be obtained by automating analysis and … complex mixtures at the intact and subunit levels using a Protein A affinity column with no sample preparation steps. …
WEBINAR: HDX-MS: a powerful tool for biopharmaceutical characterisation
Events
… technique for the advanced structural characterisation of proteins and the study of protein-protein interactions. This …
Mass spectrometry as a powerful tool for the characterisation of monoclonal antibodies in the context of comparability studies
Article
… glycoengineering of therapeutic antibodies and Fc-fusion proteins. Curr. Pharm. Biotechnol. 9, 482–501 (2008) … In …
Oligonucleotides: A serious analytical challenge in terms of analytical characterisation
Article
… Oligonucleotides: A serious challenge in terms of analytical … by Arnaud Delobel , R&D Director at Quality Assistance S.A. Oligonucleotides are a promising class of therapeutics that … we solely focus on the analytical characterisation of oligonucleotides and on the development and validation of …
Resources
… Abstract Almost 60% of commercialized pharmaceutical proteins are glycosylated. Glycosylation is considered a … as it affects the stability, bioactivity and safety of proteins. Hence, the development of analytical methods to characterise the composition and structure of glycoproteins is crucial. Currently, existing methods are …
Resources
… Host-cell proteins are a major class of process-related impurities in … . This webcast describes an alternative approach for the characterisation of the HCP coverage of these anti-HCP … be used for routine testing of residual HCPs in therapeutic proteins is appropriate. Compared to traditional Western …