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2D-LC–MS for the Analysis of Monoclonal Antibodies and Antibody–Drug Conjugates in a Regulated Environment

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… [GLP], and good clinical laboratory practice [GCLP] compliance). High-resolution MS is indeed a powerful tool … [GLP], and good clinical laboratory practice [GCLP] compliance). High-resolution MS is indeed a powerful tool …

Development and validation of an antibody-drug conjugate bioassay

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… Antibody-drug conjugates (ADCs) are a class of drugs used in the treatment of different cancers. Unlike chemotherapy, ADCs are designed to only target and kill tumour cells. Structurally, ADCs are complex molecules composed of an antibody linked to …

Development and validation of an antibody-drug conjugate bioassay: application note and video

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Development and validation of an antibody-drug conjugate bioassay

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Multiple Heartcut 2D-LC/MS: a powerful tool for biopharma analysis in a regulated environment

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… of Multiple-heartcut 2D-LC/MS at Quality Assistance : Characterisation of monoclonal antibodies Characterisation of ADCs : Hydrophobic Interaction … be achieved. MS is often required to reach low LOQ, and the protein has to be removed (offline or online) before the …

Characterisation of Antibody-Drug Conjugates by High-Resolution Mass Spectrometry

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… a powerful tool for the characterisation of two commercial ADCs, brentuximab vedotin (Adcetris ® ) and trastuzumab … set of methods has been developed to characterise ADCs at the intact, subunit, and peptide level. These … applicable to either or both lysine- and cysteineconjugated ADCs. Herein, determination of the drug load distribution …

BioRN Annual Conference 2024

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… will be participating to the BioRN Annual Conference about New Therapeutic Modalities in Personalised Medicine . Meet … capabilities towards clinical development. In addition, new insights in epigenetics, RNA biology , and molecular … and as protein replacement therapy for rare diseases. Building on its considerable experience in the analysis of …

2D UPLC/MS

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… and buffer exchange prior to MS analysis: Analysis of protein fragments and aggregates (SEC-RP/MS) Analysis of protein charge variant (SCX-RP/MS) Determination of ADCs … sample purification by affinity chromatography for protein characterisation (Immobilised Protein A column-RP/MS) …

German Biotech Days 2024

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… development and expertise in: Biotherapeutics ( mAbs , ADCs ) NCEs , oligonucleotides , peptides mRNA …

BIO International Convention

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… development and expertise in: Biotherapeutics ( mAbs , ADCs ) NCEs , oligonucleotides , peptides mRNA Viral …