Evaluation of TCR-pMHC Affinity and its implication for T Cell Therapies
Fabian Vandermeers
Lyn Zhu

Webinar co-presented with Immudex

 

During this live webinar, entitled Evaluation of TCR-pMHC Affinity and its implication for T Cell Therapies, Lyn Zhu (Immudex) and Fabian Vandermeers (Quality Assistance), discussed the following topics:

  • Challenges associated with production of high quality TCR monomers suitable for TCR affinity measurement 
  • The importance of TCR affinity measurement in the context of development of T cell therapies 
  • Introduction to two techniques used for affinity measurement: Surface Plasmon Resonance and Biolayer Interferometry, and the pros/cons of each technique 
  • Results of a case study investigating the interaction between a modified affinity-enhanced TCR targeting the NY-ESO I antigen and its cognate pMHC (HLA-A*0201 / SLLMWITQC) in terms of affinity and kinetics 
  • Recommendations on best practices for TCR-pMHC affinity measurement

 

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